Synthetic hydrogel nanoparticles for sepsis therapy

Abstract Sepsis is a life-threatening condition caused by the extreme release of inflammatory mediators into blood in response to infection (e.g., bacterial infection, COVID-19), resulting dysfunction multiple organs. Currently, there no direct treatment for sepsis. Here we report an abiotic hydrogel nanoparticle (HNP) as potential therapeutic agent late-stage The HNP captures and neutralizes all variants histones, major mediator released during highly optimized has high capacity long-term circulation capability selective sequestration neutralization histones. Intravenous injection protects mice against lethal dose histones through inhibition platelet aggregation migration lungs. In vivo administration murine sepsis model results near complete survival. These establish synthetic, nonbiological polymer sequestrants new intervention strategy therapy adds our understanding importance this condition.